

Pneumonia or acute respiratory infection treated with antibiotics in the 12 weeks prior to eligibility assessmentĬhest CT examination in the 18 months prior to eligibility assessment Unexplained weight loss of more than 15 lb in the 12 months prior to eligibility assessment Participation in a cancer prevention trial, other than a smoking cessation trial Participation in another cancer screening trial Requirement for home oxygen supplementation History of removal of any portion of the lung, excluding needle biopsy

Treatment for, or evidence of, any cancer other than non‐melanoma skin cancer or carcinoma in situ (with the exception of transitional cell carcinoma in situ or bladder carcinoma in situ) in the 5 years prior to eligibility assessment Metallic implants or devices in the chest or back, such as pacemakers or Harrington fixation rods

≥ 30 pack years of cigarette smoking historyĬurrent or former smokers (quit smoking within the previous 15 years)Ībility to lie on the back with arms raised over the head

LDCT arm: asbestos (1238), baking (603), butchering/meat packing (572), chemicals or plastics manufacturing (1642), coal mining (169), cotton or jute processing (194), farming (2837), firefighting (477), flour/feed/grain milling (290), foundry or steel milling (1159), hard rock mining (205), painting (1382), sandblasting (456), welding (1505), any of the above occupations (7448)ĬXR arm: asbestos (1288), baking (551), butchering/meat packing (593), chemicals or plastics manufacturing (1675), coal mining (162), cotton or jute processing (201), farming (2862), firefighting (513), flour/feed/grain milling (297), found ary or steel milling (1089), hard rock mining (213), painting (1431), sandblasting (457), welding (1470), any of the above occupations (7557) Number of participants: LDCT arm (26,723), CXR arm (26,733)
